Tuesday, February 24, 2009

Music-Memory Connection Found in Brain | LiveScience

Music-Memory Connection Found in Brain LiveScience

People have long known that music can trigger powerful recollections, but now a brain-scan study has revealed where this happens in our noggins.
The part of the brain known as the medial pre-frontal cortex sits just behind the forehead, acting like recent Oscar host Hugh Jackman singing and dancing down Hollywood's memory lane.
"What seems to happen is that a piece of familiar music serves as a soundtrack for a mental movie that starts playing in our head." said Petr Janata, a cognitive neuroscientist at University of California, Davis. "It calls back memories of a particular person or place, and you might all of a sudden see that person's face in your mind's eye."
Janata began suspecting the medial pre-frontal cortex as a music-processing and music-memories region when he saw that part of the brain actively tracking chord and key changes in music. He had also seen studies which showed the same region lighting up in response to self-reflection and recall of autobiographical details, and so he decided to examine the possible music-memory link by recruiting 13 UC-Davis students.
Test subjects went under an fMRI brain scanner and listened to 30 different songs randomly chosen from the Billboard "Top 100" music charts from years when the subjects would have been 8 to 18 years old. They signaled researchers when a certain 30-second music sample triggered any autobiographical memory, as opposed to just being a familiar or unfamiliar song.
"This is the first study using music to evoke autobiographical memory," Janata told LiveScience. His full study is detailed online this week in the journal Cerebral Cortex.

The students also filled out the details of their memories in a survey immediately following the MRI session, explaining the content and clarity of their recollections. Most recognized about 17 out of 30 music samples on average, with about 13 having moderate or strong links with a memory from their lives.
Janata saw that tunes linked to the strongest self-reported memories triggered the most vivid and emotion-filled responses – findings corroborated by the brain scan showing spikes in mental activity within the medial prefrontal cortex.
The brain region responded quickly to music signature and timescale, but also reacted overall when a tune was autobiographically relevant. Furthermore, music tracking activity in the brain was stronger during more powerful autobiographical memories.
This latest research could explain why even Alzheimer's patients who endure increasing memory loss can still recall songs from their distant past.
"What's striking is that the prefrontal cortex is among the last [brain regions] to atrophy," Janata noted. He pointed to behavioral observations of Alzheimer's patients singing along or brightening up when familiar songs came on.
Janata said that his research merely tried to establish a neuroscience basis for why music can tickle memory. He voiced the hope that his and other studies could encourage practices such as giving iPods to Alzheimer's patients – perhaps providing real-life testament to the power of music.
"It's not going to reverse the disease," Janata said. "But if you can make quality of life better, why not?"

Wednesday, February 18, 2009

Forensic Science System Needs Overhaul | LiveScience

Forensic Science System Needs Overhaul LiveScience

On CSI, forensic science nearly always leads to a closed case. Reality is far different. And the system needs vast change, a new report claims.
With the exception of nuclear DNA analysis, says the report from the National Research Council, "no forensic method has been rigorously shown able to consistently, and with a high degree of certainty, demonstrate a connection between evidence and a specific individual or source."
That means fingerprinting techniques and lie detection methods, among others, can lead to convictions of innocent people and, of course, fail to help convict bad guys. The report writers were careful not to pass judgment on any specific past cases, however. Rather, they looked at the overall state of things.
Other studies have shown the weaknesses of some common methods used in courtrooms:
In 2002, a study by the National Academy of Sciences revealed that "polygraph tests can discriminate lying from truth telling at rates well above chance, though well below perfection."
A study in 2005 found that though people often claim to recognize a suspect they had spotted from hundreds of feet away, a person with 20/20 vision can't recognize a celebrity's face at 110 feet.
A study in the Journal of Criminal Law & Criminology indicated that there are hundreds of errors made each year in fingerprint matching.
The new, congressionally mandated report "finds serious deficiencies in the nation's forensic science system and calls for major reforms and new research," according to a statement released today by the National Academy of Sciences.
Rigorous and mandatory certification programs for forensic scientists are lacking, the report says, as are strong standards and protocols for analyzing and reporting on evidence.
Non-DNA forensic disciplines have important roles, the report states, but many need substantial research to validate basic premises and techniques, assess limitations, and discern the sources and magnitude of error. "There is a dearth of peer-reviewed, published studies establishing the scientific bases and reliability of many forensic methods," the committee writes. "Moreover, many forensic science labs are underfunded, understaffed, and have no effective oversight."
Meanwhile, laws governing how crime is prosecuted vary greatly by state. Recently, Washington state proposed to collect DNA samples from suspects in cases as minor as shoplifting. Yet in Los Angeles, the police department recently was found to have in cold storage nearly 7,000 untested DNA samples from sexual assault cases. Last year the department let the deadline pass for prosecuting some 200 potential sexual assault cases without ever testing DNA evidence on file that might have resulted in convictions.
"Reliable forensic evidence increases the ability of law enforcement officials to identify those who commit crimes, and it protects innocent people from being convicted of crimes they didn't commit," said committee co-chair Harry T. Edwards, senior circuit judge and chief judge emeritus of the U.S. Court of Appeals for the District of Columbia Circuit. "Because it is clear that judicial review alone will not cure the infirmities of the forensic science community, there is a tremendous need for the forensic science community to improve."
Edwards and his colleagues today urged Congress to establish a new, independent National Institute of Forensic Science to lead research efforts, set and enforce standards for forensic science professionals and laboratories, and oversee education standards.

Idea of Infinity Stretched Back to Third Century B.C. | LiveScience

Idea of Infinity Stretched Back to Third Century B.C. LiveScience


CHICAGO - The first mathematical use of the concept of actual infinity has been pushed back some 2,000 years via a new analysis of a tattered page of parchment on which a medieval monk in Constantinople copied the third century B.C. work of the Greek mathematician Archimedes.
Infinity is one of the most fundamental questions in mathematics and still remains an unsolved riddle. For instance, if you add or subtract a number from infinity, the remaining value is still infinity, some Indian philosophers said. Mathematicians today refer to actual infinity as an uncountable set of numbers such as the number of points existing on a line at the same time, while a potential infinity is an endless sequence that unfolds consecutively over time.
The parchment page comes from the 348-page Archimedes Palimpsest, the oldest copy of some of the Greek genius' writings, which were hidden for centuries because a monk partly scraped them off the animal-skin parchment in the 13th century A.D. to clear the pages to print a prayer book. Also, a forger painted pictures over the prayer book hundreds of years after that.
A scholar named Johan Ludvig Heiberg in 1906 studied the written remnants behind the religious words to discover the Palimpsest, finding evidence of Archimedes' systematic use of the concept of infinity in a portion of the document called the Method of Mechanical Theorems. In the past few years, the Palimpsest was re-examined at a far higher level of detail using multispectral imaging and also a hair-thin X-ray scanning technique at Stanford University's Synchrotron Radiation Lightsource in California. The scanner can image a million pixels in less than one hour.
With one of the X-ray images, Stanford classicist Reviel Netz made out the edge of a torn page, where Heiberg had figured just one line of text was missing. The X-rays produced images of iron from the ink used on the document.
Netz examined the scan and was able to deduce the presence of previously unseen Greek letters, kappa and alpha, which were likely followed by an iota to spell the Greek word for "and." This led Netz to conclude that two lines were missing, rather than one and to arrive at a new reading of the passage, physicist Uwe Bergmann of the Synchrotron facility told a small group of reporters here Sunday at the American Association for the Advancement of Science.
"Scholars are now talking about some new words which are emerging in the reconstruction of the evidence in introduction to the Method, that Archimedes' concept of infinity was rather different from what was previously thought," Bergmann said.
In fact, the new reading reveals that Archimedes was engaged in math that made conceptual use of actual infinity, as Netz describes on the Web site ArchimedesPalimpsest.org. The calculations involved adding infinite numbers of sums, such as the number of triangles inside a prism, as well as the number of lines inside a rectangle. Archimedes tried to argue that these values are equal to each other, making a statement about actual infinity, not just potential infinity, Nets writes.
The Palimpsest resides at the Walters Museum of Art in Baltimore.
The Archimedes Palimpsest project forced researchers to come up with a new system to scan large objects, Bergmann said. A commercial-grade X-ray scanning machine might take a year to complete a scan that the Stanford Synchrotron now can complete in half a day, he said.
"It is now taking milliseconds rather than seconds to get each pixel — that has been for us the great novelty," he said.

Monday, February 16, 2009

New Artificial DNA Points to Alien Life | LiveScience

New Artificial DNA Points to Alien Life LiveScience

CHICAGO — A strange, new genetic code a lot like that found in all terrestrial life is sitting in a beaker full of oily water in a laboratory in Florida, a scientist said today, calling it the first example of an artificial chemical system that is capable of Darwinian evolution.
The system is made of the four molecules that are the basic building blocks of our DNA along with eight synthetic modifications of them, said biochemist Steven A. Benner of the Foundation for Applied Molecular Evolution in Gainesville.
The main difference between the synthetic molecules and those that make up conventional DNA is that Benner's molecules cannot make copies of themselves, although that is just "a couple of years" away, he said.
The wild biochemistry finding, described to a small group of reporters today at the annual meeting of the American Association for the Advancement of Science, offers ideas about new types of life for scientists to look for beyond our planet, or even possibly hidden on our planet.
"Unless it happens to shoot at you with a ray gun, the life that you encounter off of Earth will not necessarily have same biochemistry as us," Benner said.
And the step from Benner's system to something that could be called artificial life is still large. "There is not enough information in them to build organisms," Benner said.
Expanded alphabet for DNA
For some 20 years, Benner's labs have been involved in trying to make artificial life or things approximating it, with similar genetic and inheritance properties to life on Earth. (Previously, Benner worked at the University of Florida.)
He and his colleagues have focused in part on expanding the DNA alphabet to develop an "Artificially Expanded Genetic Information System," which now has its own supporting molecular biology.
The building blocks of DNA are four chemicals called nucleotides that are referred to as A, C, T and G, for short. The nucleotides pair up and bond in predictable ways to form the double helix structure of DNA. Benner's new nucleotides, which he and his colleagues have named Z, P, V, J, Iso-C, Iso-G, X and K, are reshufflings of the constituents of those molecules found in our DNA.
The evolution in this system happens when the 12-letter genetic code makes copying mistakes and subsequent sequences have properties that make them more liable to get copied. Those sequences would survive in greater numbers than the original sequence.
Benner's synthetic approach was conceptualized using "ball and stick plastic model chemistry," he said, the technique used by James Watson and Francis Crick to arrive at the structure of the DNA molecule in 1953.
The human genome's DNA includes 3 billion base pairs. Some of the molecules synthesized in Benner's lab are 81 base pairs long — relatively short.
The molecules are "fed" and grow via a process called the polymerase chain reaction (PCR) that allows the molecules to make copies of themselves. Once the replication of the molecules in Benner's system is self-catalyzed, without PCR, the process is self-sustaining. Benner claims, "then it's artificial life."
Dreaming up extra-terrestrial life
The research resulted from a NASA-funded project to try to understand what life might look like beyond Earth. Such life might live in water, but it could also live in liquid nitrogen or methane (as speculated for Saturn's moon Titan) and in environments with extremely high or low acidity.
The results are published in a technical book, "Life, the Universe and the Scientific Method," of which Benner has made about 100 copies to distribute to his colleagues.
"One of the ways scientists try to understand life as a universal concept ... is you try to make life on your own in the lab," Benner said. "We try to put together chemicals that do that."
Any potential life forms made from such molecules would be "so alien in terms of their biochemistry that they will not able to eat you," Benner said.
NASA has been involved in searching for extra-terrestrial life along numerous avenues for decades, including the Viking mission to Mars in the 1970s and its recent missions to the red planet which have searched for signs of habitability there. NASA also funds an Astrobiology Institute, which partners with hundreds of researchers world-wide who study of the origins, evolution, distribution and future of life in the universe
The trick to searching for alien life is how to look for it, said Paul Davies of Arizona State University, who also spoke with reporters here today.
"All of the techniques which microbiologists use to [look for alien life] are customized to life as we know it," Davies said. "It's no surprise that microbiologists haven't come across micro-organisms that seem to have relatively different biochemistry."
In the future, more scientists could "talk with Steve Benner," Davies said, "to come up with perfectly good molecules that life could use — but doesn't."

Monday, February 9, 2009

Scientist Catches Criminals Online | LiveScience

Scientist Catches Criminals Online LiveScience

Editor's Note: ScienceLives is an occasional series that puts scientists under the microscope to find out what makes them tick. The series is a cooperation between the National Science Foundation and LiveScience.
Name: Roman YampolskiyAge: 29Institution: University of LouisvilleField of Study: Behavioral Biometrics (Computer Science)
Roman Yampolskiy has chosen a career path that combines two often disparate fields, human behavior and computer science, to help find ways to catch criminals by monitoring their online behavior. From poker-website phishing schemes to coordinated website attacks, Yampolskiy looks at activity patterns to deduce who might be committing crimes online. More details, including articles about his work, are available at his website:
What inspired you to choose this field of study? I was always interested in better understanding people around me; I even had a psychology concentration as an undergraduate. After enrolling in graduate school I realized that the field of behavioral biometrics (profiling people's behavior for security purposes) offers me a great chance to combine my interest in investigation of human behavior with my desire to work with cutting edge computer technologies.
What is the best piece of advice you ever received? A good friend once told me: "Don't stress about problems. In life 50 percent of problems will resolve by themselves and there is nothing you can do about the rest."
What was your first scientific experiment as a child? When I was about 3 or 4 years old and had just learned numbers, I wanted to write down ALL the numbers sequentially starting with one. After I run out of paper in my notepad I discovered the concept of infinity and terminated my experiment which really disappointed my parents who by that time have grown attached to the peace and quiet associated with my scientific experiment. Not surprisingly they have encouraged me to pursue science ever since.
What is your favorite thing about being a scientist or researcher? Being a scientist means never having to grow up and lose curiosity inherent to all children. As a scientist I can always ask "why" about anything and in some cases be the first person to truly know that the answer is not "because."
What is the most important characteristic a scientist must demonstrate in order to be an effective scientist? A scientist believes that everything which has not been proven impossible may be possible, an effective scientist knows that nothing is impossible if you pick the right set of axioms.
What are the societal benefits of your research?Today behavioral biometric systems are utilized to provide enhanced level of security at border crossing, airports, workplaces and in numerous computer networks. It is predicted that in the near future majority of authentications tasks will be performed by relying on physical or behavioral biometrics. Results of my research in particular are aimed at financial institutions and online casinos trying to secure their customers from phishing (theft of identity) attacks.
Who has had the most influence on your thinking as a researcher? I have to say the founding father of computer science, Alan Turing, is the person who influenced my thinking the most. By helping allies win WWII by decrypting Nazi communications he showed that even theoretical mathematicians armed with computers could have an immediate positive impact on the world.
What about your field or being a scientist do you think would surprise people the most?Most people know about the stereotype of an absentminded scientist incapable of taking care of his most mundane needs while being a world famous export in his field. I myself was really surprised to learn that many accomplished computer scientists lack basic computer skills such as ability to read HTML enabled emails, open compressed files or update their own webpage.
If you could only rescue one thing from your burning office or lab, what would it be? My PhD diploma, I have multiple backup copies of everything else in my office securely located in remote locations.
What music do you play most often in your lab or car?I pride myself on the diversity of my musical tastes. I have numerous compiled CDs where Beethoven, ABBA and Eminem are located on neighboring tracks.

Thursday, February 5, 2009

Divorce Makes Women Look Older | LiveScience

Divorce Makes Women Look Older LiveScience

Divorce is one of several factors now found to add years to a woman's face.
Lots of things make us old. Previous research has shown smoking causes premature aging in men and women, literally etching the aging in their faces. Other research has found that poor skin tone can add a decade to a woman's perceived age.
In the new work, researchers photographed the faces of 186 pairs of identical twins, mostly women, and asked them each a series of questions about their life habits and medical backgrounds. Four other people then reviewed all the photos and guessed the ages of each person.
Women who were divorced were judged to look nearly two years older than their siblings who were married, single or widowed, according to an article at the The Los Angeles Times web site. The research was led by Bahman Guyuron, chairman of the department of plastic surgery at University Hospitals Case Medical Center, part of Case Western Reserve University. It was reported in the journal Plastic and Reconstructive Surgery.
Only the results for women were released. Other factors that made one twin look older than a sibling:
Sun exposure
Smoking and alcohol use
Antidepressant use
Antidepressants may cause facial sagging, Guyuron speculated.
Interestingly, being heavier made those under age 40 look older, but it made those over 40 look younger, Guyuron and colleagues report. Previous research has suggested that a little weight — particularly in the cheeks — looks good on people as they age. Predictably for a plastic surgeon, Guyuron said his findings support "fillers" used in plastic surgery.
For those who prefer to keep the looks they're given, perhaps some comfort can be found in the old adage "you're only as old as you feel." A study in December found that older people tend to feel about 13 years younger than their chronological age.

Tuesday, February 3, 2009

Orphan Chimpanzees Cleverer Than Humans, Study Finds

Orphan Chimpanzees Cleverer Than Humans, Study Finds

ScienceDaily (Feb. 2, 2009) — Orphaned chimpanzee infants given special ‘mothering’ by humans are more advanced than the average child at nine months of age.

In the first study to examine the effect of different types of care for infant chimpanzees on cognition, researchers found chimpanzees who were given extra emotionally-based care were more cognitively advanced than human infants.
Humans overtake chimpanzees in development terms as they grow older but the study sends stark warnings that looking after just an infant’s physical needs is likely to result in a child who is maladjusted, unhappy and under-achieving.
The study was carried out by psychology expert Professor Kim Bard, of the Centre for the Study of Emotion at the University of Portsmouth.
She said: “The attachment system of infant chimpanzees appears surprisingly similar to that found in human infants. Early experiences, either of warm, responsive care-giving or of extreme deprivation, have a dramatic impact on emotional and cognitive outcomes in both chimpanzees and humans.
“Parental sensitivity is an important factor in human infant development, contributing to emotionally and cognitively strong children, and it would seem the same is true for great apes, as well.”
Professor Bard studied 46 chimpanzees in the Great Ape Nursery at the Yerkes National Primate Research Centre in Atlanta, America, in the 1980s and 1990s. The chimpanzees were in the nursery because their mothers’ maternal skills were so inadequate the infants were at risk of dying.
She found that chimpanzees given 20 hours a week of responsive care, which looks after the emotional and physical development, were happier, more advanced and better adjusted than chimpanzees given standard institutionalised care which meets just their physical needs.
She said: “Those given responsive care were less easily stressed, less often attached to ‘comfort blankets’, had healthier relationships with their caregivers and were less likely to develop stereotypic rocking. They were also more advanced intellectually than chimpanzees reared with standard institutionalised care.”
The responsive care was given by human caregivers who would play, groom, feed and interact with the infants. The caregivers focused on nurturing emotional and communicative well-being, similar to that found in the parenting behaviour of well adjusted mother chimpanzees. This level of care lasted through the first year of life and the chimpanzees’ development was assessed at various stages using the same tests as those used to assess development and attachment in human infants.
The chimpanzees raised with standard institutionalised care were more likely to show signs of ‘disorganised attachment’, including rocking, or clasping themselves or a blanket, instead of seeking comfort from a carer when distressed. They also showed other contradictory behaviours such as being distressed in the absence of a carer but ‘freezing’ when the main carer returned after a brief absence.
In human infants, ‘disorganised attachments’ are seen in children whose parents have unresolved losses or other trauma, and/or when the infants are abused or neglected.
Dr Bard said: “Responsive care, which meets infants’ emotional as well as physical needs, stimulates cognitive and emotional development.
“Infant chimpanzees who were given this care were more advanced and less likely to develop attachment to things like security blankets than chimpanzees whose care was only meeting their physical needs.”
It is the first study to investigate individual differences in attachment relationships in great apes and is also the first intervention study with non-human primates evaluating the effects of two types of human care, differing in quality and quantity, on infant chimpanzees’ cognitive development and attachment security.
The study was co-authored by Professor Bard and Krisztina Ivan of the University of Portsmouth’s Centre for the Study of Emotion and Professor Marinus van IJzendoorn and Dr Marian Bakermans-Kranenburg of the Centre for Child and Family Studies at Leiden University in the Netherlands. Partial funding was provided by the European Commission for the Feelix Growing project. The study is published in Developmental Psychobiology.